| Factors |
Mechanisms |
Reference |
| PP2B and PP1 α |
Sequentially dephosphorylate 7SK snRNP and Cdk9 |
[16] |
| PPM1G |
Dephosphorylates Cdk9, recruited by NF-κB and Tat |
[17] |
| Tat |
Changes confirmation of 7SK RNA |
[18] |
| HIC mRNA |
Displaces 7SK RNA from 7SK snRNP by competition |
[20] |
| SRSF1&2 |
Binds the exonic-splicing enhancer sequence in nascent mRNA |
[21] |
| Calpain 2 |
Cleaves Mepce |
[22] |
| JMJD6 |
Decaps 7SK RNA and destabilizes 7SK snRNP |
[25] |
| AFF1 |
Promotes Tat’s extraction of P-TEFb from 7SK snRNP |
[55] |
| PIP7S |
Maintains 7SK snRNP integrity |
[56] |
| PP2B: Protein Phosphatase 2B; PP1α: Protein Phosphatase 1 α; 7SK snRNP: 7SK small nuclear ribonucleoprotein; PPM1G: Protein Phosphatase, Mg2+/Mn2+dependent, 1G; NF-κB: Nuclear Factor-κB; Tat: Tyrosine aminotransferase; HIC: Human I-mfa domain containing protein; SRSF: Serine/Arginine-Rich Splicing Factor; JMJD6: Jumonji C-Domain-Containing Protein 6; AFF1: AF4/FMR2 Family Member 1; P-TEFb: Positive Transcription Elongation Factor b; PIP7S:P-TEFb-Interaction Protein for 7SK Stability |
