glial
In adult mice following ischemic stroke (A), neuron-glial antigen 2 (NG2) was highly induced in pericytes (PCs) near Cluster of differentiation (CD) 31+ cells within ischemic areas. NG2 (B, C: green); CD31 (B, C: red); 4’,6-diamidino-2-phenylindole (DAPI; B, C: blue; arrows). In contrast, within contralateral non-ischemic areas (D), NG2+ cells were rarely PCs. NG2 (E: green); CD31 (E: red); DAPI (E: blue). At 8 and 24 weeks during adulthood, the number of NG2+ PCs was significantly increased within ischemic areas compared with in contralateral non-ischemic areas (F). *p<0.05 versus non-ischemic areas at each week (n = 3; F). Scale bars = 100 μm (B) and 20 μm (C, E).
Figure 3: Adult brain pericytes re-express neuron-glial antigen 2 following ischemic stroke.