Study Reference |
No of Patients |
No Cells |
Undergoing CABG |
Delivery Route |
Outcomes |
[85,89] |
1 |
800x106 |
Yes |
IM |
NYHA class, LVEF & tissue viability improved. No arrhythmias. Graft survived up to 1.5 years. Cells had skeletal muscle phenotype & aligned in parallel with cardiomyocytes. No connections formed. |
[90,92] |
8 |
871x106 |
Yes |
IM |
LVEF, tissue viability & contractility, & NYHA score improved. 5 patients developed VT. |
[87] |
4 |
300x106 |
No |
IM |
<1% myoblast survival, no inflammation, increased vessel density, cells aligned in parallel with myocardium. 4 patients developed arrhythmias. |
[89] |
11 |
221x106 |
Yes |
IM |
LVEF, tissue viability & contractility, & NYHA score improved. 1 patient developed VT. |
[91] |
9 |
4x105-5x107 |
Yes |
IM |
LVEF & contractility improved. VT observed in first 2 patients (7 patients received prophylaxis). |
[88] |
9 |
1x108 |
No |
Percutaneous transcoronary-venous |
Limited LVEF improvement. NYHA score improved. VT developed in 1 patient not receiving prophylaxis |
[93] (randomized controlled) |
n=12 SMs; n=11 controls |
30x106-600x106 |
No |
Endovascular transcatheter |
1 patient in control and 2 patients in treatment group developed VT. NYHA score improved. No effect on myocardial viability or function. |
SMs skeletal myoblasts; CABG coronary artery bypass graft; IM intramyocardial; NYHA New York heart association; LVEF left ventricular ejection fraction; VT
ventricular tachycardia