Figure 1: (A) Structure of 7, 8-dihydro-8-oxoguanine (8-oxo-Gua). 8-Oxo-Gua is formed by hydroxylation of guanine at the C-8 position. (B) Mechanism of GC-to-TA point mutation induction. OGG1 is 8-oxoguanine DNA glycosylase, which removes 8-oxo-Gua generated in DNA. |