Figure 4: The neurotrophic factors production of OECs on aligned collagen nanofibers. The expression of mRNA (A) and neurotrophic factors in culture medium (B) were examined after 7 days of culture. Both mRNA of NGF and BDNF were significant higher in OECs cultured on aligned collagen nanofibers in comparison with control cultures (*p<0.05, **p<0.01). More NGF was released into medium from cultures on collagen nanofibers compared with control cultures (*p<0.05). No significant difference was observed in GDNF expression between these two cultures.