Year Authors Disease Model Therapy Findings
2008 Alfaqeh, et al. Osteoarthritis Sheep Autologous MSC injection Articular cartilage regeneration
2008 Shibata, et al. Diabetic Polyneuropathy Rat Autologous MSC injection Improved hypoalgesia, sural nerve blood flow, and nerve conduction velocity
2008 Centeno, et al. Osteoarthritis Human Autologous MSC injection Regeneration of meniscus cartilage
2010 Yoshikawa, et al. Degenerative Disc Disease Human Autologous MSC injection Disc regeneration and decrease in back and leg pain
2011 Orozco, et al. Degenerative Disc Disease Human Autologous MSC injection Decrease in pain and disability
2011 Guo, et al. Chronic Pain Rat Autologous MSC injection Reversed mechanical hypersensitivity
2011 Waterman and Betancourt Painful Diabetic Peripheral Neuropathy Mouse Human MSC2 injection Decreased serum inflammatory cytokines, improved heat hyperalgesia and mechanical allodynia
MSC=multipotent mesenchymal stromal cells frequently referred to as mesenchymal stem cells, MSC2=anti-inflammatory mesenchymal stem cells
Table 3: Studies of painful conditions and msc therapy.