| Type of Hematopoietic Stem Cell Transplant |
Source of Stem Cells |
Risk of Early Infection: Neutrophil Depletion |
Risk of Late Infection: Impaired T and B Cell Function |
Risk of Ongoing Infection: GVHD and Iatrogenic Immunosuppression
|
Graft versus Tumor Effect |
| Autologous |
Recipient (self) |
High risk; neutrophil recovery sometimes prolonged |
1 year |
Minimal to no risk of GVHD and late-onset severe infection |
None (-) |
| Syngeneic (genetic twin) |
Identical twin |
Low risk; 1-2 weeks for recovery |
1 year |
Minimal risk of GVHD and late-onset severe infection |
+/- |
| Allogeneic related |
Sibling |
Low risk; 1-2 weeks for recovery |
1 year |
Minimal to moderate risk of GVHD and late-onset severe infection |
++ |
| Allogeneic related |
Child/parent(haploidentical) |
Intermediate risk; 2-3 weeks for neutrophil recovery |
1-2 years |
Moderate risk of GVHD and late-onset severe infection |
++++ |
| Allogeneic unrelated adult |
Unrelated donor |
Intermediate risk; 2-3 weeks for neutrophil recovery |
1-2 years |
High risk of GVHD and late-onset severe infection |
++++ |
| Allogeneic unrelated cord blood |
Unrelated cord blood units (x2) |
Intermediate to high risk; neutrophil recovery sometimes prolonged |
Prolonged |
Minimal to moderate risk of GVHD and late-onset severe infection |
++++ |
| Allogeneic mini (nonmyeloablative) |
Donor (transiently coexisting with recipient cells) |
Low risk; neutrophil counts close to normal |
1-2+ years |
Variable risk of GVHD and late-onset severe infection
|
++++ (but develops slowly) |
