Figure 1: Possible Immunosuppressive mechanisms of Autograft-Absolute Monocyte Count (A-AMC)/Monocytic Myeloid-Derived Suppressor Cells (MDSCs). This schematic diagram depicts possible immunosuppressive mechanisms of A-AMC/MDSCs including the production of immunosuppressive cytokine; disruption of the major histocompatability complex class 1 receptor causing T-cels to become unresponsive to antigen-specific; Fas-FasLinteraction leading to T-cell apoptosis; induction of regulatory T-cells; and inhibition of natural killer (NK) cells function/proliferation. Granulocyte-Colony Stimulating-Factor (G-CSF), Granulocyte- Macrophages Colony Stimulating-Factor (GM-CSF) and ± Plerixafor mobilized higher numbers of monocytes in the peripheral blood of patients leading to higher numbers of aphorized and collected A-AMC.