Figure 3: Cancer stem cell network targeted drugs for successful cancer therapy. Cancer cells and CSCs are sustained by unique protein-protein interaction (PPI) network. Chemo, radiation and other therapies can target cancer cell PPI leading to partial reduction of tumor (Left panel). On the other hand CSC networks are highly resistant and not affected by the standard regimens leading to recurring tumors (Right panel). For successful therapy a CSC network targeted regimen is needed and when combined with traditional chemotherapeutic may benefit the elimination of both cancer and CSCs.