Figure 4: Multi-target drugs have a broader impact on complex network. (Left panel) Single pathway targeted drugs have limited scope in complex networks (such as those related to CSCs). A very specific drug restricts its activity to a single protein that may or may not be part of bottleneck module. (Right panel) On the other hand, multi-targeted natural agents such as CDF have been recognized to myriad targets. For example transcription factors such as NF-kB, myc and notch that are established components of bottleneck modules. Therefore, such pleiotropic agents act as target multipliers and increase the target radius thereby showing superior cancer inhibitory effects.