Airway Cells capable of stem-like behavior Cell response to injury Normal stem cell marker Associated cancer Cancer marker
Proximal airway (trachea and Bronchi) Basal cells [10] Self–renewal and multi-potent abilities [11] Keratin 5
Transcription factor-63
Trp-63 [12]
Squamous cell carcinoma Keratin 5 [13]
Midlevel airway (Bronchioles) Clara cells [14]   Multi-potent but not self-renewal [14] Secretoglobin, scgb1a1   (CCSP or CC10) [12]        
Variant Clara cells [15]   Multi-potent and self-renewal [17] Lack cytochrome P4502F2 [15]     Small cell lung cancer   Calcitonin gene-related peptide
  Pulmonary Neuroendocrine Cells (PNEC) [16] Self–renewal [17] Calcitonin gene-related peptide [20]    
Distal airway (alveoli) Bronchoalveolar duct junction cell Self-renewal [18] CCSP [19] Bronchiolar adenocarcinoma  
Table 1: Normal lung stem cells and associated lung cancer.