Marker |
Target |
Cell numbers required for tumour formation in vivo |
Reference |
CD44+/CD24-/ESA+ |
Human breast cancers:
Basal-like, claudin low, Her2-ve, BRCA null, and medullary tumours |
200 |
[4,18] |
Cell lines |
Not tested |
[17] |
CD44+/CD49fhi/CD133+ |
ERα- tumours |
250 |
[19] |
CD49f+ |
MCF-7 cell line |
Not tested |
[21] |
CD133+ |
BRCA- mouse tumours |
50 |
[23] |
ALDH+ |
Human breast cancers:
Triple negative
ERBB2 negative |
500 |
[24] |
Cell lines e.g. SUM159 |
100 |
[26] |
CD44+/CD24-/ESA+
ALDH+ |
Human breast cancers |
20 |
[24] |
PROCR+/ESA+ |
MDA-MB-231 cell line |
100 |
[17] |
|