Figure 5: Schematic representation of therapy targeting the EGFR signaling pathway. mTOR: mammalian target of rapamycin, PDK1: 3-phospoinositidedependent protein kinase-1, PI3K: phosphatidylinositol 3-kinase, PTEN: phosphatase and tensin, RAS: rat sarcoma, TKIs, tyrosine kinase inhibitors.