PVA concentration (% w/v) Particle size (nm ) PDI 0.3 291.6 ±25.57 0.145±0.030 0.5 349.3 ± 21.82 0.176 ± 0.037 0.7 317.9 ±30.05 0.156 ±0.072

Table 3: Effect of the PVA concentration in aqueous phase on the particles size and polydispersity (PDI) at TDL 30 (% w/w), PLGA = 1.3 (% w/v), pH = 9.