30-min after patch (μg/mL) 4-hour after patch (μg/mL) 8-hour after patch (μg/mL) 16-hour after patch (μg/mL) 24-hour after patch (μg/mL) p KG 0.00018 ± 0.00051 0.054 ± 0.018 0.082 ± 0.023 0.081 ± 0.026 0.078 ± 0.028 * +KG 0.00024 ± 0.00072 0.053 ± 0.025 0.081 ± 0.019 0.08 ± 0.027 0.077 ± 0.026 ** Data expressed as mean ± STD. -Comparison in the KG at the different tomes: (KG 24-hour = KG 16-hour = KG 8-hour)> KG 4-hour > KG 30-min > KG (p<0.02) -Comparison in the +KG at the different times: (+KG 24-hour = +KG 16-hour =+KG 8-hour) > +KG 4-hour > KG 30-min (p<0. 02) -Groups KG and +KG were similar to each other when both were compared at each time interval (P>0.05)

Table 3: Venous plasmatic ketamine and S(+)-ketamine levels measured by High Performance Liquid Chromatography at different times after transdermal patch ketamine or K(+)-ketamine application