Figure 1: Infectious and non infectious insults can lead to systemic inflammatory response syndrome (SIRS). If SIRS is caused by infection, the term sepsis is used. When sepsis is accompanied by an organ system dysfunction progresses into severe sepsis and to septic shock when hypotension is added to the anterior symptoms. Multiple organ dysfunction syndrome (MODS) is defined as more than two organ dysfunction in critically ill patients. These circumstances can lead to death.