Figure 1: Thermodynamic Parameters for Binding of Antagonists and (Partial) Agonists to hH1R and gpH1R [13]. Antagonists: 1, mepyramine; 2, diphenhydramine; 3, fexofenadine; 4, terfenadine; 5, mitriptyline; 6, mianserin; 7, clozapine; 8, chlorpromazine. (Partial) agonists: 9, histamine; 10-13, phenylhistamines; 14-19, histaprodifens; 20, suprahistaprodifen; 21- 23, phenoprodifens; 24, dimeric histaprodifen.