Entry |
Concentration used |
% Growth of Inhibition |
IC50a
(ug/mL) |
Cytotoxicityb
(ug/mL) |
T. I.c |
3b |
10 ug/mL |
71.23 |
6.04 |
32 |
5.3 |
3c |
10 ug/mL |
85.53 |
4.55 |
10 |
2.2 |
3e |
10 ug/mL |
71.95 |
5.53 |
32 |
5.8 |
3g |
10 ug/mL |
85.03 |
5.24 |
25 |
4.8 |
3i |
10 ug/mL |
67.53 |
5.48 |
30 |
5.5 |
3l |
10 ug/mL |
68.88 |
2.07 |
14 |
14.5 |
3m |
10 ug/mL |
83.34 |
5.42 |
30 |
2.6 |
3p |
10 ug/mL |
54.22 |
4.54 |
28 |
6.2 |
3q |
10 ug/mL |
51.41 |
9.23 |
25 |
2.7 |
Nifurtimox |
10 ug/mL |
68.50 |
0.47 |
27 |
57.44 |
Benznidazole |
10 ug/mL |
86.77 |
0.81 |
>50 |
>62 |
*Each value is the mean of three experiments
* a IC50: concentration that produces 50% inhibitory effect, bcytotoxicity TD: dose required to produce of 50% cell LLCMK2,c TI: therapeutic index: IC50, LLC-MK2/IC50, T. cruzi. |
