compounds Diameter of growth of inhibition zone (mm)b Minimum inhibitory concentration (MIC) (μg/ml) Staphylococcus aureus Escherichia coli Pseudomonas aeroginosa Candida albicans Aspergillus niger Fusarium oxysporium Ciprofloxacin ++++ ++++ ++++ - - - Nystin - - - ++++ ++++ ++++ 3 ++ - ++ - - ++ 4 ++ - ++ ++ +++ - 5 ++ ++ - - +++ ++ 6 +++ - - ++ +++ +++ 8a - - - ++ +++ ++++ 8b ++ - ++ ++ +++ - 8c ++ +++ ++ - +++ ++ 8d ++ +++ - - +++ - – No activity aConcentration 4.0 mg/ml bValues, including diameter of the well (8 mm), are means of three replicates a The activities are based on the diameters of zones of inhibition in mm. One mL of stock solution (5.0 mg/mL in DMF) was applied in each hole of each paper disk. +: < 15 mm; ++: 15-24 mm; +++: 25-34 mm; ++++: 35-44 mm, etc.

Table 2: Bactericidal and Fungicidal Activity in vitro activity of newly synthesized Compounds and Ciprofloxacin and Nystina