Entry Substrate Reagent Product Time (min) Yieldb (%)
1 (CH3CO)2O 70 90
2 (CH3CO)2O 85 84
3 (CH3CO)2O 80 86
4 4-OMePhCOCl 95 87
5 PhCOCl 80 89
6 (CH3CO)2O 95 85
7 PhCOCl 90 83
8 PhCOCl 95 83
9 (CH3CO)2O 90 88
10 (CH3CO)2O 100 86
11 (CH3CO)2O 110 84
12 (CH3)3CH2SH PhCOCl 105 88
aAll the products are known compounds and were characterized by comparison of their NMR spectral data and physical properties with those reported in the literature [11,27,30]. bIsolated yield
Table 3: Acylation of thiols in the presence of TBAOH (20% in water)a.