Shiff base Bacteria Gram negative Gram positive B. subtilis S. aureus E.coli S. typhi VIII 17 mm 18 mm 15 mm 18 mm IX 18 mm 16 mm 16 mm 19 mm X 18 mm 15 mm 12 mm 17 mm XI         Control 00 mm 00 mm 00 mm 00 mm Ciprofloxacin 20 mm 20 mm 20 mm 20 mm

Table 6: Effect of new Macrocyclic hydrazone (VIII, IX, X, XI) on the growth of tested bacteria (conc. 200 μg/ml).