route
Scheme 2: Synthetic route developed for Brs analog 21-23. Conditions and reagents: a. K2CO3/MeOH, r.t. 6 h, 84.1%. b. Ac2O/DMAP/py/CH2Cl2, 2 h, 85.1%. c. CuSO4/(CH3)2CO, r.t. 5 days, 69.2%.