IC50 (µM)a

Selectivity

 

HepG2

HepG2-Vin

HepG2/ HepG2-Vin

3

>61

16.0

>3.8

6

43.8

2.4

18.3

Paclitaxel

0.63

2.4

0.26

aCytotoxicity as ED50 values for each cell line, the concentration of compound that caused 50% reduction in absorbance at 562 nm relative to untreated cells using the sulforhodamine B assay. Hepatocellular carcinoma (HepG2), and its MDR line (HepG2-Vin).

Table 2: MDR-selectivity of 3 and 6 against hepatocellular carcinoma