Compound

B16-F10
IC50 ± SD(μM)

U251
IC50 ± SD(μM)

HepG2
IC50 ± SD(μM)

FAK inhibition
IC50(μM)

4a

8.25±0.58

12.36±0.68

19.57±1.02

19.12

4b

12.01±0.59

18.32±0.85

22.15±0.98

20.48

4c

13.56±0.89

21±0.92

25.65±1.05

23.27

staurosporine

-

-

-

11.32

Table 2: The antiproliferative effects of the compounds of 4a-4c