Groups Parameters Insulin (µIU/mL)   C-peptide (pmol/mL)   Fasting 2 hours Fasting 2 hours Normal control 25.23±1.83b 36.43±2.26a 160.67±6.41bc 147.65±5.74a Diabetic control 10.01±0.76c 10.80±0.54c 58.05±13.85d 64.05±12.33d Diabetic treated with 4b 31.36±3.30ab 36.88±6.64a 141.97±2.04c 194.14±23.23b F-probability P<0.001   P<0.001   LSD at the 5% level 9.46   36.56   LSD at the 1% level 12.74   49.24

Data are expressed as mean ± standard error. Number of animals in each group is eight. - For each parameter, means, which share the same superscript symbol(s), are not significantly different. - If the difference between two means is higher than LSD at 5%, the effect will be significant (p<0.05). - If the difference between two means is higher than LSD at 1%, the effect will be highly significant (p<0.01).

Table 4: Effect of pyrimido[1,6-a]quinazoline derivative 4b on serum insulin and C-peptide levels at fasting state and after 2 hours of oral glucose loading in n5-STZ induced type 2 diabetic male rats.