Groups Parameters Insulin (µIU/mL) C-peptide (pmol/mL) Fasting 2 hours Fasting 2 hours Normal control 30.73±4.83b 41.91±0.64a 158.60±6.26b 209.23±21.88a Diabetic control 13.66±1.54c 14.40±1.79c 47.85±3.46d 58.74±3.95cd Diabetic treated with 4b 29.90±5.25b 34.41±5.60ab 65.19±3.40cd 172.17±10.03b F-probability P<0.001   P<0.001   LSD at the 5% level 11.07   29.91   LSD at the 1% level 14.91   40.29

Table 5: Effect of pyrimido[1,6-a]quinazoline derivative 4b on serum insulin and C-peptide levels at fasting state and after 2 hours of oral glucose loading in n5-STZ induced type 2 diabetic female rats.