Groups
Parameters
Glycogen (mg/g tissue)
Glycogen phosphorylase (mU/100mg tissue)
Glucose-6-phosphatase (mU/100mg tissue)
Glucokinase (mU/100mg tissue)
Normal control
6.96±0.98a
11.39±0.32b
21.97±0.56b
32.52±0.17b
Diabetic control
4.56±0.29b
21.46±3.64a
31.32±2.37a
32.82±0.83b
Diabetic treated with 4b
5.56±0.28ab
11.10±0.91b
29.05±1.07a
44.65±2.07a
F-probability
P<0.05
P<0.01
P<0.01
P<0.001
LSD at the 5% level
1.84
6.56
4.61
4.84
LSD at the 1% level
2.55
9.07
6.38
6.69
Table 6:
Effect of pyrimido[1,6-a]quinazoline derivative 4b on liver glycogen content and glycogen phosphorylase, glucose-6-phosphatase and hexokinase activities in n5-STZ induced type 2 diabetic male rats.