| |
|
Water |
GFJ |
| |
|
mean ±SD |
mean ±SD |
p-value |
| Active HMG-CoA reductase inhibitors |
| Cmax |
(ng/mL) |
1.94 ±0.69 |
2.73 ±1.10 |
NS |
| Tmax |
(hr) |
2.3 ±0.1 |
3.6 ±1.8 |
NS |
| AUC |
(0-8hr) |
8.7 ±3.7 |
14.5 ±6.3 |
0.024 |
| Active HMG-CoA reductase inhibitors |
| Cmax |
(ng/mL) |
7.11 ±3.17 |
8.54 ±2.89 |
NS |
| Tmax |
(hr) |
1.5 ±0.5 |
1.8 ±0.9 |
NS |
| AUC |
(0-8hr) |
22.9 ±6.7 |
38.2 ±11.2 |
0.002 |
|