Simvastatin/Grapfruit juice/day Cmax AUC  　　　 W/G-Active W/G-Total W/G-Active W/G- Total ng/ml (p) ng/ml (p)           60mg/1200ml (3) 3.1/ 20.3  15.6/ 147.0 21.7/ 147.0 46.6/ 752                    (p<0.001) ( p <0.01)    (p<0.05) 40mg/1200ml (4) 3.9/ 19.6 9.3/ 112.0 24.9/ 114.0  27.8/ 373.0 (p<0.001) (p<0.001)    40mg/200ml　(5) 2.6/ 11.1 7.3/ 28.5 18.5/ 62.0 31.6/ 112.5 (p<0.001)  (p<0.001)

W: water group, G: grapefruit juice group, Active: concentration of active simvastatin acid, Total: concentration of total simvastatin Active Inhibitors*: Active HMG-CoA reductase inhibitors Total Inhibitors*: Total HMG-CoA reductase inhibitors Ng-eq/ml** refers to the nanogram equivalents of simvastatin acid

Table 2: Review of the literature measuring active and total simvastatin level with regard to interaction of grapefruit juice with simvastatin.