Polymer used
Preparation Method
Particle size (nm)
Polydispersity
Zeta potential (mV)
PLGA
O/W emulsion solvent evaporation method
209.1±1.0
0.050
-23.96±1.2
PLGA-PEG-FOL
200.9±0.1
0.180
-8.96±1.1
W/O/W double emulsion solvent evaporation method
192.5±4.1
0.108
-15.2± 2.7
Dialysis method
2504.9±208.5
0.249
-14.46±1.3