Comd |
R |
R1 |
Rf Vlaue |
Yield (%) |
M.P(°C) |
AchEa
IC50( µM)±SEM |
BuchE b
IC50( µM)±SEM |
Selectivity for AChEc |
3a |
Pyridyl- |
H |
0.67 |
74 |
204 |
0.42±0.02 |
3.4±0.02 |
8.09 |
3b |
4-flurophenyl- |
H |
0.64 |
65 |
183 |
1.12±0.02 |
2.12±0.02 |
1.89 |
3c |
3,4-Dimethoxy phenyl-- |
H |
0.69 |
72 |
194 |
3.2±0.02 |
1.2±0.02 |
0.37 |
3d |
Phenyl- |
H |
0.62 |
80 |
161 |
1.12±0.1 |
3.10±0.1 |
2.76 |
3e |
2-Chloro phenyl- |
H |
0.78 |
82 |
138 |
1.8±0.01 |
4.3±0.01 |
2.3 |
3f |
Pyridyl- |
Cl |
0.73 |
85 |
113 |
0.37± 0.01 |
3.8± 0.01 |
10.20 |
3g |
4-flurophenyl- |
Cl |
0.76 |
92 |
126 |
1.6±0.1 |
3.7±0.1 |
2.3 |
3h |
3,4-Dimethoxy phenyl-- |
Cl |
0.74 |
85 |
105 |
2.2±0.1 |
4.2±0.1 |
1.90 |
3i |
Phenyl- |
Cl |
0.66 |
77 |
154 |
3.2±0.1 |
11.2±0.1 |
3.50 |
3j |
2-Chloro phenyl- |
Cl |
0.70 |
82 |
162 |
2.6±0.1 |
6.6±0.1 |
2.50 |
3k |
Pyridyl- |
NO2 |
0.78 |
90 |
126 |
0.10±0.1 |
4.10±0.1 |
36.41 |
3l |
4-flurophenyl- |
NO2 |
0.82 |
56 |
178 |
8.6±0.1 |
1.6±0.1 |
0.18 |
3m |
3,4-Dimethoxy phenyl- |
NO2 |
0.85 |
81 |
194 |
6.10±0.1 |
3.10±0.1 |
0.50 |
3n |
Phenyl- |
NO2 |
0.59 |
76 |
172 |
13.2±0.1 |
2.2±0.1 |
0.16 |
3o |
2-Chloro phenyl- |
NO2 |
0.83 |
72 |
182 |
7.6±0.1 |
1.6±0.1 |
0.20 |
Drug |
Donepezil.HCl |
- |
- |
- |
- |
0.12±0.01 |
3.6±0.1 |
30.0 |
|