Groups
Parameters
Insulin (µIU/mL)
C-peptide (pmol/mL)
Fasting
2 hours
Fasting
2 hours
Normal control
30.73±4.83
b
41.91±0.64
a
158.60±6.26
b
209.23±21.88
a
Diabetic control
13.66±1.54
c
14.40±1.79
c
47.85±3.46
d
58.74±3.95c
d
Diabetic treated with 4b
29.90±5.25
b
34.41±5.60
ab
65.19±3.40
cd
172.17±10.03
b
F-probability
P<0.001
P<0.001
LSD at the 5% level
11.07
29.91
LSD at the 1% level
14.91
40.29
Table 5:
Effect of pyrimido[1,6-a]quinazoline derivative 4b on serum insulin and C-peptide levels at fasting state and after 2 hours of oral glucose loading in n5-STZ induced type 2 diabetic female rats.