Groups
Parameters
Glycogen (mg/g tissue)
Glycogen phosphorylase (mU/100mg tissue)
Glucose-6-phosphatase (mU/100mg tissue)
Glucokinase (mU/100mg tissue)
Normal control
8.20±0.32
a
14.15±1.14
b
28.04±1.01
b
50.93±6.09
a
Diabetic control
4.63±0.39
c
29.36±3.29
a
32.89±1.53
a
56.89±8.49
a
Diabetic treated with 4b
6.74±0.41
b
12.79±1.04
b
28.97±1.21
b
63.65±8.96
a
F-probability
P<0.001
P<0.001
P<0.05
P>0.05
LSD at the 5% level
1.14
6.32
3.82
-
LSD at the 1% level
1.58
8.74
5.29
-
Table 7:
Effect of pyrimido[1,6-a]quinazoline derivative 4b on liver glycogen content and glycogen phosphorylase, glucose-6-phosphatase and hexokinase activities in n5-STZ induced type 2 diabetic female rats.