Groups Parameters Total thiol (nmole/100mg) Glutathione (nmole/100mg) Lipid Peroxidation (nmole MDA/100mg) Glutathione reductase (U/g) Glutathione peroxidase (mU/100mg) Glutathione-S-transferase (U/100mg) Catalase (k.102)
Normal 247.13±0.94b 56.78±2.39ab 51.65±1.27a 12.02±0.19a 96.20±4.61b 37.71±3.38a 71.85±1.63a
Diabetic control 203.50±0.90c 53.50±0.90b 54.65±0.02a 11.20±0.31ab 77.80±0.67c 40.68±2.43a 61.55±3.69a
Diabetic treated with 4b 257.32±1.91a 60.49±0.89a 45.27±2.58b 10.89±0.32b 120.97±3.25a 21.28±1.63a 72.33±4.32a
F-probability P<0.001 P<0.05 P<0.01 P<0.05 P<0.001 p>0.05 p>0.05
LSD at the 5% level 4.03 4.71 5.01 0.85 9.87 - -
LSD at the 1% level 5.57 6.51 6.93 1.17 13.66 - -
Table 10: Effect of pyrimido[1,6-a]quinazoline derivative 4b on oxidative stress and antioxidant defense markers in liver of n5-STZ induced type 2 diabetic male rats.