Groups
Parameters
Total thiol (nmole/100mg)
Glutathione (nmole/100mg)
Lipid Peroxidation (nmole MDA/100mg)
Glutathione reductase (U/g)
Glutathione peroxidase (mU/100mg)
Glutathione-S-transferase (U/100mg)
Catalase (k.102)
Normal
247.13±0.94
b
56.78±2.39
ab
51.65±1.27
a
12.02±0.19
a
96.20±4.61
b
37.71±3.38
a
71.85±1.63
a
Diabetic control
203.50±0.90
c
53.50±0.90
b
54.65±0.02
a
11.20±0.31a
b
77.80±0.67
c
40.68±2.43
a
61.55±3.69
a
Diabetic treated with 4b
257.32±1.91
a
60.49±0.89
a
45.27±2.58
b
10.89±0.32
b
120.97±3.25
a
21.28±1.63
a
72.33±4.32
a
F-probability
P<0.001
P<0.05
P<0.01
P<0.05
P<0.001
p>0.05
p>0.05
LSD at the 5% level
4.03
4.71
5.01
0.85
9.87
-
-
LSD at the 1% level
5.57
6.51
6.93
1.17
13.66
-
-
Table 10:
Effect of pyrimido[1,6-a]quinazoline derivative 4b on oxidative stress and antioxidant defense markers in liver of n5-STZ induced type 2 diabetic male rats.