Groups
Parameters
Total thiol (nmole/100mg)
Glutathione (nmole/100mg)
Lipid Peroxidation (nmole MDA/100mg)
Glutathione reductase (U/g)
Glutathione peroxidase (mU/100mg)
Glutathione-S-transferase (U/100mg)
Catalase (k.102)
Normal
241.72±4.59
a
63.13±2.94
a
44.27±1.38
ab
10.88±0.90
a
96.30±1.18
b
33.52±23.78
a
60.27±0.99
b
Diabetic control
203.33±14.33
b
54.93±1.56
b
48.92±4.29
a
10.24±0.03
a
88.87±1.67
b
26.62±2.05
b
72.08±3.35
a
Diabetic treated with 4b
235.85±4.13
ab
59.85±0.83
ab
37.23±1.84
b
10.58±0.28
a
134.1±10.35
a
26.45±1.64
b
57.38±5.79
b
F-probability
P<0.05
P<0.05
P<0.05
P>0.05
P<0.001
P<0.05
P<0.05
LSD at the 5% level
27.16
5.95
8.48
-
8.17
6.17
11.76
LSD at the 1% level
37.55
8.23
11.73
-
11.29
8.53
16.27
Table 11:
Effect of pyrimido[1,6-a]quinazoline derivative 4b on oxidative stress and antioxidant defense markers in liver of n5-STZ induced type 2 diabetic female rats.