|
σ1 Receptor Binding Parameters |
σ2 Receptor Binding Parameters |
Compound |
IC50 (nM) |
Ki (nM) |
Hill Slope |
IC50 (nM) |
Ki(nM) |
Hill Slope |
1, (Z)-IA-SA4503 |
15.45 ± 1.91 |
10.67 ± 1.32 |
1.01 ± 0.09 |
18.78 ± 1.24 |
16.71 ± 1.20 |
1.15 ± 0.04 |
2, (E)-IA-SA4503 |
24.48 ± 1.85 |
16.91 ± 1.28 |
1.06 ± 0.08 |
20.45 ± 2.23 |
18.20 ± 1.99 |
0.96 ± 0.01 |
ao-BON |
6.4 ± 0.7 |
NR |
NR |
10.2 ± 1.9 |
NR |
NR |
am-BON |
8.9 ± 2.8 |
NR |
NR |
54.5 ± 6.6 |
NR |
NR |
bSA4503 |
6.67 ± 0.30 |
4.63 ± 0.21 |
1.23 ± 0.06 |
70.93 ± 4.86 |
63.09 ± 4.33 |
0.88 ± 0.05 |
Binding parameters for 1 and 2 are means ± SEM for four to six assays, each performed in duplicate. aData from [15]. bData from [19]. NR = not reported |