aIC50 represents the concentration of a compound to bring out 50% inhibition of MMP-13; expressed as pIC50 on molar basis; taken from reference [28,29].| aIC50 represents the concentration of a compound to bring out 50% inhibition of MMP-13; expressed as pIC50 on molar basis; taken from reference [28,29]. |
| Chart 1: Structural variations and MMP-13 inhibition activity of non-zinc-chelating compounds (see Figure 1 for general structure). |