Compound N-N E IC50/mMa
3a TMEDA   4.33 ± 0.05
3b bpy   4.34 ± 0.05
3c dmbpy   4.35 ± 0.05
3d phen   4.36 ± 0.05
4a TMEDA O 3.02 ± 0.04
4b bpy O 3.03 ± 0.04
4c dmbpy O 3.05 ± 0.04
4d phen O 3.14 ± 0.04
5a TMEDA S 3.014 ± 0.04
5b bpy S 3.022 ± 0.04
5c dmbpy S 3.012 ± 0.06
5d phen S 3.027 ± 0.05
aMTT assay from DMSO stock solution on human leukaemic K562 cells. (1h exposure)
Table 1: In vitro activity of palladacycles against a K562 cell line.