Compound A % Neurotoxicity B % Neurotoxicity
Control 0/5 0 0/5 0
DMSO 1/5 20 1/5 20
IVa 2/5 40 2/5 40
VIb 3/5 60 0/5 0
IVc 0/5 0 5/5 100
VIc 3/5 60 1/5 20
IVd 2/5 40 0/5 0
clozapine 3/5 60 1/5 20
A = number of mice fall from the screen
B = number of mice that fail to climb the top of the screen
Table 4: Evaluation of neurotoxicity of test compounds and clozapine (3 mg/kg, i.p.) using horizontal screen test in mice.