Compound
A
% Neurotoxicity
B
% Neurotoxicity
Control
0/5
0
0/5
0
DMSO
1/5
20
1/5
20
IV
a
2/5
40
2/5
40
VI
b
3/5
60
0/5
0
IV
c
0/5
0
5/5
100
VI
c
3/5
60
1/5
20
IV
d
2/5
40
0/5
0
clozapine
3/5
60
1/5
20
A = number of mice fall from the screen
B = number of mice that fail to climb the top of the screen
Table 4:
Evaluation of neurotoxicity of test compounds and clozapine (3 mg/kg, i.p.) using horizontal screen test in mice.