| Entry |
5-LOX inhibitory activity (Anti-inflammatory activity) |
Antioxidant activity (Radical scavenging activity) |
| In vitro studies
IC50 (μg/ml) |
Insilico studies
Dock score (Kcal/mol) |
DPPH |
Superoxide
IC50 (μg/ml) |
| 4a |
9.7 |
-138.67 |
10.99 |
9.8 |
| 4b |
ND |
-110.76 |
8.3 |
7.8 |
| 4c |
13.1 |
-129.32 |
8.5 |
7.6 |
| 4d |
13.3 |
-128.21 |
8.8 |
7.5 |
| 4e |
14.1 |
-124.87 |
10.0 |
9.1 |
| 4f |
15.4 |
-119.67 |
9.5 |
9.8 |
| 4g |
15.3 |
-118.56 |
15.4 |
19.8 |
| 4h |
9.2 |
-141.23 |
5.6 |
7.6 |
| 4i |
12.2 |
-122.65 |
13.1 |
14.2 |
| 6a |
14.6 |
-126.61 |
14.2 |
14.3 |
| 6b |
13.4 |
-121.01 |
10.0 |
13.1 |
| 6c |
13.5 |
-127.21 |
9.3 |
10.3 |
| 6d |
14.4 |
-129.34 |
12.2 |
10.9 |
| 6e |
10.4 |
-118.32 |
15.5 |
13.03 |
| 6f |
10.1 |
-108.49 |
16.43 |
15.02 |
| 6g |
10.1 |
-119.94 |
14.45 |
13.5 |
| 6h |
21.0 |
-102.56 |
8.7 |
10.3 |
| 6i |
26.5 |
-99.23 |
10.2 |
11.2 |
| 6j |
29.2 |
-98.92 |
11.2 |
11.9 |
| Standard* |
4.40 |
-154.92 |
3.6 |
3.3 |
* Nordihydroguaiaretic acid for 5-LOX, Ascorbic acid for antioxidant activity, ND; Not Determined. |