Compound
Ar
R
Activity (at sixth hour) Blood glucose level mg/dl
B1
220.0
B2
206.3
B3
200.3
B4
271.5
B5
270.8
B6
267.8
B7
266.5
B8
199.0
B9
195.3
B10
265.8
B11
169.5
B12
271.5
B13
210.0
B14
206.3
B15
198.3
B16
200.0
B17
195.3
B18
169.5
Table 2:
Thiadiazole compounds B1 to B18 as antidiabetic were used as reference structures.