Compound Ar R Activity (at sixth hour) Blood glucose level mg/dl
B1 220.0
B2 206.3
B3 200.3
B4 271.5
B5 270.8
B6 267.8
B7 266.5
B8 199.0
B9 195.3
B10 265.8
B11 169.5
B12 271.5
B13 210.0
B14 206.3
B15 198.3
B16 200.0
B17 195.3
B18 169.5
Table 2: Thiadiazole compounds B1 to B18 as antidiabetic were used as reference structures.