Propertie  Compound Inhibition of JAKs IC50 (nM) Structure Pharmacophore JAK1 JAK2 JAK3 TYK2 Tasocitinib 3.3 2.8 19 428 pyrrolopyrimidine Ruxolitinib 3.2 4.1 1.6 19 pyrrolopyrimidine Baricitinib 59 57 － － pyrrolopyrimidine

Table 2: Comparison of Tasocitinib, Ruxolitinib, Baricitinib.