Compound Pb18  Pb03      Pb01   Pb339  µg/mL    µmol/L µg/mL       µmol/L µg/mL   µmol/L µg/mL    µmol/L 1 32.2 120 31.2 120.0 - - - - 2 62.5 248.0 31.2 127.0 125.0 504.0 250.0 120.0 3 62.5 214.0 1.9 6.5 125.0 428.0 125.0 428.0 4 500 1582.0 250.0 791.0 - - - - 5 ≥500 ≥2049.0 31.2 127.8 - - - - 6 500 1724.0 62.5 215.5 - - - - 7 62.5 196.5 7.8 24.5 125.0 393.0 125.0 393.0 8 31.2 93.9 15.6 46.9 125.0 376.0 62.5 188.2 Amphotericin B 0.06 0.06 0.02 0.02 0.06 0.06 0.06 0.06 Trimethoprim/ sulfamethoxazole 300 987.10/ 172.20 300.0 987.10/ 172.20 75.0 246.4/ 43.0 75.0 246.4/ 43.0 -: not determined;

Table 1: Antifungal activity of phebalosin and compounds derivatives against clinical isolates of Paracoccidioides.