| Compd. |
R |
X |
Inhibition ratios for AChE (%)a |
Inhibition ratios forBChE (%)a |
| 5a |
 |
0 |
7.88 ± 3.58 |
1.19 ± 0.59 |
| 5b |
 |
1 |
90.40 ± 1.23 |
26.05 ± 2.52 |
| 5c |
 |
1 |
37.02 ± 2.07 |
13.77 ± 1.05 |
| 5d |
 |
1 |
34.49 ±2. 76 |
9.02 ± 0.23 |
| 5e |
 |
2 |
19.28 ± 1.87 |
11.72 ± 0.82 |
| 5f |
 |
2 |
10.19 ± 0.44 |
9.52 ± 1.48 |
| 5g |
 |
2 |
16.54 ± 1.36 |
17.88 ± 2.83 |
| 5h |
 |
2 |
51.04 ± 0.55 |
39.20 ± 5.64 |
| Rivastigmine |
- |
- |
86.45 ± 0.71 |
94.60 ± 3.19 |
|
| aInhibition ratios for AChE and BChE in the presence of 50 μM compound (means ± SEM of two experiments), AChE from electric eel, BChE from equine serum. |
| Table 1: Inhibitory activity of target compounds for AChE and BChE. |