| |
10-minute incubation |
2-hour incubation |
| Comp. |
R |
n |
IC50 (mM) |
SD |
IC50 (mM) |
SD |
| 4 |
H |
1 |
6.79 |
0.12 |
1.58 |
0.54 |
| 5 |
CH3 |
1 |
3.72 |
0.26 |
0.78 |
0.07 |
| 9 |
H |
0 |
8.85 |
1.67 |
2.59 |
0.51 |
| 10 |
CH3 |
0 |
12.01 |
0.13 |
2.12 |
0.16 |
| Diltiazem |
0.26* |
0.06 |
0.14 |
0.02 |
| Verapamil |
0.45** |
0.12 |
0.12 |
0.11 |
|
| Experiments were repeated for four times for each compound at each incubation>
time tested. |
| *Reported 0.30 μM [20], ** Reported 0.47 μM [20]. |
| Table 1: IC50 (μM) values of hybrid compounds, diltiazem and verapamil after
10-minute and 2-hour incubation times |