| Compound |
ED50 (µmol/kg) |
| |
Leukocyte migration |
TNF-α production |
| ASA |
128.0* |
N.R. |
| imatinib |
5.0* |
0.44* |
| 2c (LASSBio-1597) |
5.1* |
4.4* |
| 6 (LASSBio-1724) |
5.35* |
9.26* |
| 7 (LASSBio-1725) |
6.1* |
8.8* |
| 8 (LASSBio-1726) |
3.2* |
8.6* |
| 9 (LASSBio-1723) |
4.45* |
0.07* |
| 10 (LASSBio-1727) |
5.4* |
0.9* |
|
| -N.R. not realized; ASA = acetylsalicylic acid. N=7-10 per group. Doses: 1-50 (µmol/kg). Statistical significance between groups was calculated using analysis of variance (ANOVA) followed by Bonferroni test. P values less than 0.05 (*p < 0.05) were used as significant level. |
| Table 3: Effects of carboxamides 2c, 6-10, imatinib and acetylsalicylic acid (ASA) in leukocyte migration and TNF-α production induced by carrageenan injection into the subcutaneous air pouch. |