Metabolicpathway Associted genes
Adipocyte funtion and lipid metabolism ABCG1, APOE, ADRB3, CYP19A1,FABP2, LEPR, LRP2, MTP, PPARG
Beta cell dysfunction of the pancreas CPN10, HNF4A, TCF1, SUR1,KIR6.2,SLCA2A, UCP2, IAPP, INS, GCK, SIRT1,ARNT, FOXO1, NNT
Cellcycleregulators HHEX1/IDE, CDKAL1, CDK2A/B, CDC123/CAMKLD,TSPAN8, THADA, PALGPS2
Cytoesqueleton and extracelular matrix ADAMTS9, ARHGEF11, ELMO1, NXPH1
Energetic Balance PGC1,SIRT1, UCP2
Incretinsystem DPPIV, GLP1, GIP, KCNQ1,KCNJ11
Inflamation ADIPOQ, HLA-G, IL-6, TNFA
Liverfuntion GYS1,GCGR, IGF1, IGFBP2, HNF1A
Mechanism of insulin in tissue ATXN2, ATXN3, ENPP1, FTO, INSR, IRS1, IRS2, PIK3,PP1R3A, RBP4
Morphognsis of the pancreas FOXO1,FOXA2, JAZF1, NOTCH2, RORA,TCF7L2
Proteosome UBQLNL
Trace elements and mineral metabolism SLC30A8
Transporterstoaromaticaminoacids SLC16A11, SLC16A13
Vascular and hypothalamic disfuntion ELMO1, HPSE, HPSG, ICF7L2, NOS3, NXPH1
Table 1: Major genes associated with type 2 diabetes mellitus