Compound
n
OH
n
LS
Σ
n
M
(i)IC
50
(1)/
M
(1)IC
50
(i)
1
3.30
0.17
3.47
1.0
29
3.41
1.35
4.76
1.5 (1.54)
30
3.41
1.35
4.76
3.3
31
3.41
1.35
4.76
2.2
32
3.41
1.35
4.76
1.6
33
2.58
1.84
4.42
0.3 (0.06)
34
0.0
2.0
2.0
0.02 (0.02)
35
0.0
2.0
2.0
0.02 (0.02)
Table 4:
Comparison of the antimalarial activity of dispiro-1,2,4-trioxalanes 29-35 (35,45) with the number of free radicals, which are formed due to their intramolecular