Compound nOH nLS Σn M(i)IC50(1)/M(1)IC50(i)
1 3.30 0.17 3.47 1.0
29 3.41 1.35 4.76 1.5 (1.54)
30 3.41 1.35 4.76 3.3
31 3.41 1.35 4.76 2.2
32 3.41 1.35 4.76 1.6
33 2.58 1.84 4.42 0.3 (0.06)
34 0.0 2.0 2.0 0.02 (0.02)
35 0.0 2.0 2.0 0.02 (0.02)
Table 4: Comparison of the antimalarial activity of dispiro-1,2,4-trioxalanes 29-35 (35,45) with the number of free radicals, which are formed due to their intramolecular