Compound nOH nLS IC50(i)/M(i) IC50(1)M(i)/ IC50(i) M(1) {IC50(1)M(i)/
 IC50(i) M(1)}OH
1 3.17 1.17 12.5 1.00 1.00
36 3.83 0.83 7.2 1.74 13.1
37 3.42 1.69 8.2 1.52 2.65
38 3.42 1.69 138.1 0.09 2.65
39 3.42 1.69 6.3 1.98 2.65
40 3.42 1.69 12.5 1.00 2.65
41 3.42 1.69 3.8 3.30 2.65
42 3.42 1.69 6.6 1.89 2.65
43 3.42 1.69 4.3 2.91 2.65
44 3.42 1.69 13.3 0.94 2.65
45 3.42 1.69 22.5 0.55 2.65
46 3.42 1.69 12.6 0.99 2.65
Table 5: Comparison of the antimalarial activity of compound 1 and hybrid derivatives of 10-dihydroartemisinin (36 − 46) (47) with the number of hydroxyl radicals nOH, which
are formed due to their intramolecular oxidation (48).