Compound
n
OH
n
LS
IC
50
(i)/
M
(i)
IC
50
(1)
M
(i)/ IC
50
(i)
M
(1)
{IC
50
(1)
M
(i)/
IC
50
(i)
M
(1)}OH
1
3.17
1.17
12.5
1.00
1.00
36
3.83
0.83
7.2
1.74
13.1
37
3.42
1.69
8.2
1.52
2.65
38
3.42
1.69
138.1
0.09
2.65
39
3.42
1.69
6.3
1.98
2.65
40
3.42
1.69
12.5
1.00
2.65
41
3.42
1.69
3.8
3.30
2.65
42
3.42
1.69
6.6
1.89
2.65
43
3.42
1.69
4.3
2.91
2.65
44
3.42
1.69
13.3
0.94
2.65
45
3.42
1.69
22.5
0.55
2.65
46
3.42
1.69
12.6
0.99
2.65
Table 5:
Comparison of the antimalarial activity of compound 1 and hybrid derivatives of 10-dihydroartemisinin (36 − 46) (47) with the number of hydroxyl radicals n
OH
, which
are formed due to their intramolecular oxidation (48).