| Compd. |
IC50(μM) |
| B16 |
A549 |
Bel-7402 |
K562 |
| Taxolb |
0.96 ± 0.01 |
0.72 ± 0.04 |
0.45 ± 0.10 |
0.91 ± 0.02 |
| 2 |
29.87± 3.64 |
33.08 ± 0.15 |
39.67± 4.22 |
42.03± 1.21 |
| 3 |
20.62± 1.02 |
29.70 ± 0.34 |
33.78± 2.12 |
38.33± 1.31 |
14
15a |
19.39± 0.18
7.98 ± 0.29 |
20.92± 1.60
9.34 ± 0.54 |
21.85± 0.73
11.97 ± 0.06 |
22.69± 0.09
12.23 ± 0.12 |
| 15b |
10.75 ± 0.14 |
10.09 ± 0.20 |
14.87 ± 0.24 |
15.56 ± 0.52 |
| 15c |
11.92 ± 0.09 |
11.27 ± 0.33 |
15.01 ± 0.09 |
16.14 ± 0.43 |
| 15d |
9.65 ± 0.31 |
9.60 ± 0.14 |
11.95 ± 0.19 |
12.48 ± 0.31 |
| 15e |
9.71 ± 0.20 |
10.62 ± 0.11 |
14.70 ± 0.20 |
16.22 ± 0.14 |
| 15f |
10.01 ± 0.13 |
10.33 ± 0.07 |
15.85 ± 0.12 |
16.01 ± 0.30 |
| 15g |
11.89 ± 0.08 |
12.91 ± 0.05 |
15.54 ± 0.09 |
17.96 ± 0.11 |
| 15h |
16.74 ± 0.12 |
17.74 ± 0.09 |
18.01 ± 0.04 |
19.41 ± 0.26 |
| 15i |
20.81 ± 0.14 |
21.87 ± 0.28 |
22.70 ± 0.15 |
25.05 ± 0.14 |
| 20a |
6.40 ± 0.42 |
8.05 ± 0.12 |
9.02 ± 0.16 |
8.46 ± 0.05 |
| 20b |
6.93 ± 0.06 |
9.71 ± 0.30 |
10.17 ± 0.01 |
10.08 ± 0.06 |
| 20c |
6.98 ± 0.04 |
10.03 ± 0.05 |
13.06 ± 0.03 |
12.10 ± 0.07 |
| 20d |
6.29 ± 0.22 |
8.78 ± 0.19 |
9.08 ± 0.42 |
9.34 ± 0.15 |
| 20e |
7.13 ± 0.16 |
9.85 ± 0.11 |
10.21 ± 0.08 |
11.72 ± 0.12 |
| 20f |
7.97 ± 0.14 |
9.92 ± 0.16 |
13.13 ± 0.15 |
13.98 ± 0.08 |
| 20g |
11.15 ± 0.31 |
10.94 ± 0.14 |
14.98 ± 0.13 |
15.81 ± 0.10 |
| 20h |
15.16 ± 0.18 |
16.72 ± 0.17 |
17.81 ± 0.10 |
16.56 ± 0.09 |
| 20i |
19.27 ± 0.15 |
20.60 ± 0.16 |
21.02 ± 0.11 |
23.14 ± 0.08 |
aResults are expressed as IC50 values in μM. b Taxol was used as a positive control. |